Whether the class QMA (Quantum Merlin Arthur) is equal to QMA1, or QMA with one-sided error, has been an open problem for years. This note helps to explain why the problem is difficult, by using ideas from real analysis to give a "quantum oracle" relative to which QMA and QMA1 are different. As a byproduct, we find that there are facts about quantum complexity classes that are classically relativizing but not quantumly relativizing, among them such "trivial" containments as BQP in ZQEXP.